We’ve known for decades that asthma was more prevalent in women than in men, and that asthma tended to persist in girls more often than boys, but the reason behind this difference has been a question that remained unanswered until recently.

Scientists found that testosterone actually protects against asthma by preventing certain immune cells from developing and maturing, which in turn reduces allergic inflammation in the lungs. This allergic inflammation is the cause of asthma in most people. Testosterone acts directly on these important immune cells to suppress the inflammatory response.

This may also help to explain why we see boys “outgrow” asthma more than girls, often around puberty.

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